I can not add much more, it really is up to you. This nothing to do with Gimp and all about your objectives.
If you design a large image (say for a Wall Tapestry) what about those small details that will vanish when printed for a small sticker. Have you considered the various types of "printed-on" materials and suitability of image?
IMHO unlikely to be a problem because they will be different sets of customers with very different requirements - so one size or the other will be redundant.
The topic has strayed a bit from a 800 x 600 pix drawing of a skull with a transparent background
Best of luck with your work.
If you design a large image (say for a Wall Tapestry) what about those small details that will vanish when printed for a small sticker. Have you considered the various types of "printed-on" materials and suitability of image?
IMHO unlikely to be a problem because they will be different sets of customers with very different requirements - so one size or the other will be redundant.
The topic has strayed a bit from a 800 x 600 pix drawing of a skull with a transparent background
Best of luck with your work.